Orgeta 2015.

Study characteristics
Methods	RCT
Participants	N = 356 (165 F/191 M) Mild‐to‐moderate dementia according to DSM‐IV criteria 76% receiving AChEI medication Mean MMSE 21.2 (SD 4.3) Age 78.2 (SD 7.5) Community
Interventions	Individual cognitive stimulation (delivered by informal caregivers) (N = 180) Treatment‐as‐usual controls (N = 176)
Outcomes	Cognition: ADAS‐Cog; MMSE Quality of Life: QoL‐AD (self‐report and proxy); DEMQOL (self‐report and proxy) Quality of relationship: Quality of the Carer‐Patient Relationship Scale (QCPR) ADL: Bristol ADL Scale Mood: GDS‐15 Behaviour problems: NPI Caregiver outcomes: Short Form‐12 Health Survey (physical (PCS) and mental (MCS) components); Hospital Anxiety & Depression Scale (HADS); EQ‐5D‐3L; Resilience Scale‐14; NPI carer distress; QCPR
Notes	30 minutes, 3 times a week, for 25 weeks Imputed adjusted means used in meta‐analysis
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"Randomisation was completed using a dynamic adapative allocation method, with an overall allocation ratio of 1: 1. Random allocation was stratified by site and receipt of acetylcholinesterase inhibitors (AChEIs)."
Allocation concealment (selection bias)	Low risk	Randomisation database held at trials unit; only unblinded researchers informed of allocation
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Assessors blinded
Incomplete outcome data (attrition bias) All outcomes	Low risk	Full details given on attrition. ITT analyses used
Selective reporting (reporting bias)	Low risk	Results given for all planned outcomes
Other bias ‐ training and supervision	Low risk	Carers all received training in delivering iCST and support throughout study.
Other bias ‐ treatment manual	Low risk	Carers all received standardised training package and manual (Yates 2014).