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. 2023 Jan 31;2023(1):CD005562. doi: 10.1002/14651858.CD005562.pub3

Paddick 2017.

Study characteristics
Methods Stepped wedge design
Participants N = 34 (29F/5M)
Dementia according to DSM‐IV criteria
None receiving AChEI medication
Mean Clinical Dementia Rating 1.65 (range 1‐2)
Median age 80 (IQR 76.5‐85.3)
Community
Interventions Cognitive stimulation groups (N = 16)
Wait‐list controls (N = 18)
Outcomes Cognition: ADAS‐Cog
Quality of life: World Health Organization Quality of Life assessment (WHOQOL)
Mood: Hospital Anxiety & Depression Scales
ADL: World Health Organization Disability Assessment Schedule (WHODAS 2.0)
Behaviour problems: NPI
Caregiver outcomes: WHOQOL; Zarit Burden Inventory; Hospital Anxiety & Depression Scales; NPI Caregiver distress
Notes 45 minutes, twice a week, for 7 weeks
Relevant comparison was at assessment 8 weeks after baseline, where those who received cognition stimulation could be compared with the wait‐list controls, who had received treatment‐as‐usual. Only ADAS‐Cog data were available for this comparison.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Cluster‐randomised. Simple randomisation with random number generator
Allocation concealment (selection bias) Low risk Randomisation carried out by independent statistician, blinded to participant allocation
Blinding of outcome assessment (detection bias)
All outcomes Low risk Outcome assessors were blind to group allocation and did not deliver the CST sessions; participants reminded not to disclose
Incomplete outcome data (attrition bias)
All outcomes Low risk Intention‐to‐treat protocol ‐ no attrition in relation to comparison of immediate and delayed start groups
Selective reporting (reporting bias) High risk Although all outcome measures were reported for the comparison of interest (between immediate and delayed start CST groups), only data on ADAS‐Cog provided
Other bias ‐ training and supervision Low risk Facilitators received training on CST in the UK and had been involved in the adaptation and pilot of adapted CST for Sub‐Saharan Africa.
Other bias ‐ treatment manual Low risk Published manual ‐ adapted from CST manual