Tsantali 2017.

Study characteristics
Methods	RCT
Participants	N = 55 Mild Alzheimer's disease according to NINCDS‐ADRDA and DSM‐IV‐TR criteria All receiving AChEI medication for at least two years Mean MMSE 23.0 (SD 1.3) Age 73.7 (SD 5.3) Community
Interventions	Individual cognitive stimulation delivered by psychologists (N = 17) Individual cognitive training delivered by psychologists (N = 17) Treatment‐as‐usual controls (N = 21)
Outcomes	Cognition: MMSE; CAM‐COG; Boston Naming Test; Pyramids and Palm Trees Test; Rivermead Behavioural Memory Test
Notes	90 minutes, 3 times a week, for 4 months Data for post‐treatment assessment requested ‐ not received; only 8‐month follow‐up data available
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"Participants were...randomly allocated by lot into the three conditions".
Allocation concealment (selection bias)	Unclear risk	No detail provided on the randomisation process
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Clinicians conducting assessments were blinded.
Incomplete outcome data (attrition bias) All outcomes	High risk	Per protocol analysis ‐ 4/21 dropped out from cognitive stimulation group; 0/21 from control group
Selective reporting (reporting bias)	Unclear risk	Very little reported of results at post‐treatment ‐ nearly all data seems to be from 12‐month follow‐up.
Other bias ‐ training and supervision	Low risk	"Four licensed psychologists, who had sufficient clinical experience in providing cognitive remediation programmes to an aging population administered the programmes." Activities according to specialisation
Other bias ‐ treatment manual	High risk	No indication of a manual or a particular structure for the cognitive stimulation