Table 3.
Ex vivo saturation (Sa) and sieving (Sc) coefficients, and transmembrane clearance (CLTM, mL/min) of cefepime in a human blood-crystalloid solution for each CRRT modality using a polyarylethersulfone (HF-1000) membrane.
| CRRT Modality | Sa or Sc Coefficients | CLTM (mL/min) |
|---|---|---|
| CVVH | 1.20 (.08)† | 15.96 (1.06) |
| CVVHD | 1.29 (.09)* | 17.23 (1.24) |
| CVVHDF | 1.17 (.07)* | 15.63 (.94) |
All values are presented as mean (SD) and were calculated using sample times from 15 minutes to 4 hours. *Sa = saturation coefficient. †Sc = sieving coefficient. CRRT, continuous renal replacement therapy; CVVH = continuous venovenous hemofiltration; CVVHD = continuous venovenous hemodialysis; CVVHDF = continuous venovenous hemodiafiltration.