Fig 1. Motivation for sustained–delivery implants for treatment of PDAC.

Sustained–delivery implants are a promising treatment methodology over conventional single free–drug intravenous or intrantumoural injections. A hypothetical comparison of drug concentrations at the tumour site under these two protocols is pictured. Systemic injections of anti–cancer drugs often result in only a fraction of the drug arriving at the tumour site followed by a rapid decrease of drug concentration at the tumour site. In comparison, sustained–release mechanisms deliver drug over a prolonged period resulting in a durable drug presence at the tumour site. Created using biorender.com.