Table 3. The 50% growth inhibition concentration (GI50) for each individual compound.
| Cell lines | IKE (μM) | Erastin (μM) | RSL-3 (μM) | SAS (μM) | l-Glutamate (μM) | FIN46 (μM) | Cisplatin (μM) | Staurosporine (μM) | Mitomycin C (μM) |
|---|---|---|---|---|---|---|---|---|---|
| HEY | 25.5 ± 0.48 | 225.32 ± 0.22 | 3.68 ± 0.09 | 2,000 ± 30.6 | 252,020 ± 117 | 75.25 ± 0.48 | 250 ± 1.93 | 2.22 ± 0.29 | 40.51 ± 0.40 |
| SKOV-3 | 18 ± 0.16 | 16.23 ± 0.16 | 1.85 ± 0.01 | 1,250 ± 9.73 | 241,300 ± 62.9 | 68 ± 0.16 | 230 ± 1.92 | 6.75 ± 0.59 | 33.29 ± 0.33 |
| CAOV-3 | 31.25 ± 0.20 | 22.1 ± 0.02 | 3.2 ± 0.25 | 1,300 ± 10.64 | 195,690 ± 97.7 | 65.02 ± 0.21 | 120 ± 3.21 | 12.35 ± 0.99 | 55.01 ± 1.60 |
| OSE | 24 ± 0.31 | 31.25 ± 0.31 | 1.48 ± 0.03 | 460 ± 8.70 | 156,700 ± 88.8 | 62.26 ± 1.71 | 52 ± 1.73 | 4.24 ± 0.13 | 10.8 ± 0.18 |
| OVCAR-3 | 28 ± 0.01 | 21.8 ± 0.01 | 0.98 ± 0.02 | 470 ± 20.1 | 196,150 ± 100 | 31.25 ± 0.19 | 130 ± 3.25 | 4.97 ± 0.54 | 23.96 ± 0.23 |
| A2780 | 24.3 ± 0.02 | 27.3 ± 0.98 | 1.65 ± 0.07 | 1,170 ± 11.5 | 215,510 ± 136 | 91.25 ± 0.27 | 100 ± 1.52 | 13.25 ± 0.87 | 9.44 ± 0.45 |
| OVC-201 | 20.15 ± 0.02 | 24.6 ± 1.16 | 1.23 ± 0.09 | 952 ± 30.42 | 221,343 ± 157 | 75.96 ± 0.23 | 74 ± 1.55 | 4.99 ± 0.56 | 1.136 ± 0.09 |
| OVC-302 | 27 ± 0.97 | 27.2 ± 0.02 | 1.68 ± 0.09 | 1,270 ± 9.13 | 216,090 ± 142 | 78.7 ± 0.97 | 58 ± 0.98 | 16.32 ± 1.82 | 50.19 ± 0.98 |
| OVCAR-8 | 22.35 ± 0.02 | 15.5 ± 0.03 | 0.16 ± 0.03 | 1,240 ± 25.7 | 168,570 ± 71.2 | 20.71 ± 0.22 | 99 ± 2.01 | 1.3 ± 0.39 | 60.32 ± 1.05 |
| FT-246 | 3.2 ± 0.03 | 2.86 ± 0.06 | 0.112 ± 0.02 | 730 ± 24.3 | 101,300 ± 106 | 20.35 ± 0.35 | 155 ± 4.41 | 10.25 ± 0.82 | 34.7 ± 0.88 |
| OVC-205 | 15.26 ± 0.11 | 12.36 ± 0.30 | 1 ± 0.04 | 700 ± 13.6 | 180,700 ± 103 | 15.25 ± 0.11 | 96 ± 1.73 | 13.57 ± 0.67 | 23.69 ± 0.48 |
| SW626 | 10.15 ± 1.09 | 4.85 ± 0.02 | 1.65 ± 0.25 | 760 ± 17.5 | 115,610 ± 157 | 20 ± 1.09 | 240 ± 4.68 | 8.09 ± 0.37 | 44.25 ± 0.78 |
| MES-OV | 1.6 ± 0.04 | 8.21 ± 0.03 | 0.45 ± 0.05 | 420 ± 25.2 | 103,960 ± 44.4 | 4.65 ± 0.42 | 140 ± 2.51 | 14.21 ± 0.51 | 27.04 ± 0.27 |
| SKOV-3 NRF2 KO-1 | 2.01 ± 0.03 | 2.8 ± 0.05 | 0.15 ± 0.03 | 521 ± 4.87 | 95,052 ± 31.9 | 20.56 ± 0.31 | 42 ± 0.21 | 5.99 ± 0.16 | 30.25 ± 0.17 |
| SKOV-3 NRF2 KO-2 | 2.32 ± 0.01 | 3.01 ± 0.04 | 0.16 ± 0.02 | 533 ± 5.63 | 98,665 ± 70.2 | 18.22 ± 0.18 | 45 ± 0.63 | 4.99 ± 0.26 | 34.25 ± 0.10 |
| SKOV-3 NRF2 KO-3 | 2.11 ± 0.03 | 2.95 ± 0.03 | 0.13 ± 0.04 | 495 ± 9.33 | 90,355 ± 42.5 | 21.25 ± 0.32 | 51 ± 0.5 | 5.86 ± 0.44 | 31.25 ± 0.16 |