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. 2023 Feb 1;14(2):75. doi: 10.1038/s41419-023-05574-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Representative microscopy images of the (inguinal) SCAT of young adult and aged hamsters at 0 (mock), 7, and 22 dpi (H&E staining). At 7 dpi, one can note the presence of CLSs in the SCAT of young-adult animals, and the presence of fibrosis in the SCAT of the aged animals (inserts: higher magnification). B Representative immunochemical (IHC) staining for F4/80 (left panels) highlighted the presence of macrophages (in brown) clustered around adipocytes. Representative IHC staining for lipid-droplet-specific perilipin-1 (right panels) highlighted live (stained) adipocytes (in brown, black arrows) and damaged/dead (non-stained, red arrows) adipocytes in the SCAT of young adults and aged adults at 7 dpi. C Representative images of dead adipocytes in the SCAT of young adult and aged hamsters at 0 (mock), 7, and 22 dpi. IHC staining for perilipin-1 shows live (stained) adipocytes. A higher magnification image is shown for aged adult animals at 7 dpi. Live adipocytes are indicated by yellow stars, and damaged/dead adipocytes are indicated by red stars. Lipid spillovers are indicated by black arrows. A–C scale bars = 100 μm. B, C Slides were counterstained with Mayer’s hematoxylin.