Table 7.
Interactions of ketoconazole with the plant extracts against yeast Candida isolates.
| Yeast species | T. mauritianum (aerial parts) | L. macrocarpa (leaves) | C. bougheyanum (aerial parts) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FICA | FICB | ∑FIC | Interpretation | FICA | FICB | ∑FIC | Interpretation | FICA | FICB | ∑FIC | Interpretation | |
| Candida dubliniensis 5 : I52 | 0.125 | 0.125 | 0.25 | Synergistic | 0.015 | <1 | <2 | Indifferent | 0.015 | 0.25 | 0.3 | Synergy |
| Candida dubliniensis 1 : I59 | 1 | 0.25 | 1.25 | Indifferent | 1 | <1 | <2 | Indifferent | 0.25 | 0.5 | 0.75 | Additive |
| Candida dubliniensis 3 : I81 | 0.125 | 0.25 | 0.375 | Synergistic | 0.5 | 0.25 | 0.75 | Additive | 0.5 | 0.125 | 0.625 | Additive |
| Candida albicans 7Ca | 1 | 0.25 | 1.25 | Indifferent | 0.031 | 0.125 | 0.156 | Synergistic | 0.5 | 0.125 | 0.625 | Additive |
| Candida albicans 11Ca | 0.5 | 1 | 1.5 | Indifferent | 0.5 | <1 | 1 | Indifferent | 0.25 | 1 | 1.25 | Indifferent |
| Candida albicans 18Ca | 0.25 | 0.125 | 0.375 | Synergistic | 0.5 | 0.25 | 0.75 | Additive | 1 | 0.25 | 1.25 | Indifferent |
| Candida albicans Cppc BACT 017 | 0.25 | 0.25 | 0.25 | Synergistic | 0.25 | 0.125 | 0.375 | Synergistic | 0.5 | 0.5 | 1 | Additive |
| Candida glabrata 11 : I81 | 0.5 | 1 | 1.5 | Indifferent | 0.25 | 0.125 | 0.375 | Synergistic | 0.25 | 0.125 | 0.375 | Synergy |
| Candida glabrata 10 : I39 | 0.5 | 0.25 | 0.75 | Additive | 0.25 | 0.25 | 0.5 | Synergistic | 0.25 | (0.25) | 0.5 | Synergy |
| Candida tropicalis Cpc BACT 018 | 1 | 0.25 | 1.25 | Indifferent | 0.25 | 0.125 | 0.375 | Synergistic | 0.25 | <1 | <2 | Indifferent |
FICA: MIC of the ketoconazole tested in combination/MIC of ketoconazole tested alone; FICB: MIC of the extract tested in combination/MIC of the extract tested alone; ∑FIC: FICA + FICE.