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. 2023 Jan 5;14(1):493–507. doi: 10.1002/jcsm.13153

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© 2023 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Muscle fibre size 21 days after BaCl₂ injury. (A) Examples of gastrocnemius cross sections of uninjured control muscles of phosphate‐buffered saline (PBS)‐treated mice (21C) or mitochondrial transplant therapy (MTT)‐treated mice (21CM). Examples of muscle cross sections are shown where injured muscles were allowed to repair for 21 days after systemic PBS treatment (21R) and systemic MTT treatment (21RM). Fibre type was identified by immunocytochemistry of myosin heavy chains. Type IIA fibres (green), Type IIB fibres (orange/gold), Type IIX fibres (black) and Type I fibres (red). The white bar is 200 μm in length. (B) Examples of gastrocnemius cross sections of uninjured control muscles of phosphate‐buffered saline (PBS)‐treated mice (21C) or mitochondrial transplant therapy (MTT)‐treated mice (21CM). Examples of muscle cross sections are shown where injured muscles were allowed to repair for 21 days after systemic PBS treatment (21R) and systemic MTT treatment (21RM). Fibre type was identified by immunocytochemistry of myosin heavy chains. Type IIA fibres (green), Type IIB fibres (orange/gold), Type IIX fibres (black) and Type I fibres (red). The white bar is 200 μm in length. (SD for each animal. Control non‐injured (PBS injected) muscles from PBS sham‐treated (21C) or MTT‐treated mice (21CM). Injured (BaCl₂ injected) muscles from PBS‐treated (21R) or MTT‐treated mice (21RM). (C–F) Fibre frequency histograms (C,D) and cumulative frequency distributions (E,F) for Type IIA (C,E) and Type IIB (D,F) fibres. (C,D) The corresponding control non‐injured muscle data for the frequency histograms (21C or 21CM) are represented by shaded bars. The blue line represents data from PBS sham‐treated mice 14 days post‐injury (21R). The green line represents data from MTT‐treated mice after 14 days of injury (21RM). (E,F) Cumulative frequency distribution for non‐damaged control muscle data (21C, circle or 21CM, inverted triangle). The blue line, PBS‐injected mice 21 days post‐injury (21R). The green line, MTT‐injected mice after 21 days of injury (21RM).