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. 2022 Dec 5;614(7946):136–143. doi: 10.1038/s41586-022-05605-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — (a) Tumour volume after B16-F10-OVA cell engraftment at ZT9 and OVA vaccination at ZT9 (120 h after tumour engraftment, n = 11) or ZT21 (108 h, n = 12, or 132 h, n = 11 mice, after tumour engraftment); from 2 independent experiments, two-way ANOVA. (b-c) Numbers of DC subsets (b) and T cells (c) in the draining LN 24h after OVA vaccination (on day 5 after B16-F10-OVA cell engraftment) in control or Clec9acre:Bmal1^flox mice, n = 5 mice from 2 independent experiments, unpaired Student’s t-test. (d) Tumour volume in WT mice after tumour engraftment (5×10⁵ B16-F10-OVA cells) at ZT9 or ZT21, with or without OVA vaccination on day 5 (arrow) at ZT9 or ZT21, n = 4 mice, two-way ANOVA. (e) Tumour volume after B16-F10-OVA cell engraftment at ZT9 and OVA vaccination on day 5 and 8 (arrows), both at ZT9 or ZT21 (n = 6 mice) or unvaccinated controls (n = 9 mice), from 2 independent experiments, two-way ANOVA. (f) qPCR of human PER2 expression in human monocyte derived DCs (hMoDC) after synchronization, n = 3 patients, Cosinor analysis. All data are represented as mean ± SEM, ns, not significant, all t-tests are two-tailed.

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