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. 2022 Dec 5;614(7946):136–143. doi: 10.1038/s41586-022-05605-0

Extended Data Fig. 4. Time-of-day differences exist in other tumour models.

Extended Data Fig. 4

(a-d) DCs and T cell numbers in the dLN, 24h after tumour engraftment of MC-38 cells (n = 6 mice) (a), 4T1 cells (n = 6 mice) (b), or E0771-OVA cells, n = 7 (ZT9), n = 6 (ZT21) mice, (c-d), from 2 independent experiments, unpaired Student’s t-test. (c) Gating of anti-mouse H-2Kb bound to SIINFEKL+ DCs in the E0771-OVA model. (e-g) T cell numbers in the dLN 72h after tumour engraftment of E0771-OVA cells, n = 5 (ZT9), n = 7 (ZT21) (e), or MC-38 cells, n = 6 mice (f-g), from 2 independent experiments, unpaired Student’s t-test. (f) Gating of Dextramer H-2Db/ ASMTNMELM bound to CD8 T cells in the MC-38 model and, (g) quantification. All data are represented as mean ± SEM, all t-tests are two-tailed.

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