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. 2023 Jan 25;614(7946):118–124. doi: 10.1038/s41586-022-05637-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — (a) Robust principal-component analysis of microbiome beta-diversity 18 weeks after feeding mice with a low fat diet (LFD, n = 10), serine/glycine-free LFD (-SG LFD, n = 10), high fat diet (HFD, n = 9), and serine/glycine-free HFD (-SG HFD, n = 9). (b) Log-ratio of species with complete vs. incomplete pathways for L-serine biosynthesis 18 weeks after feeding mice with a low fat diet (LFD, n = 10), serine/glycine-free LFD (-SG LFD, n = 10), high fat diet (HFD, n = 9), and serine/glycine-free HFD (-SG HFD, n = 9). (c) Log-ratio of species with complete vs. incomplete pathways for glycine cleavage 18 weeks after feeding mice with a low fat diet (LFD, n = 10), serine/glycine-free LFD (-SG LFD, n = 10), high fat diet (HFD, n = 9), and serine/glycine-free HFD (-SG HFD, n = 9). (d) Log fold-change of microbiome species 18 weeks after feeding mice with a low fat diet (LFD, n = 10), serine/glycine-free LFD (-SG LFD, n = 10), high fat diet (HFD, n = 9), and serine/glycine-free HFD (-SG HFD, n = 9). Data are presented as a minimum/maximum (b–c) and were analyzed using a PERMANOVA test (a) and a two-way ANOVA with Fisher’s LSD post hoc test (b–c).