FIG. 7.

Schematic representation of the function of the Yop-specific chaperones in secretion. (A) The Yop-specific chaperone binds to the translocation domain of its cognate Yop protein. (B) In the absence of the respective chaperone, secretion of the Yop is impaired. (C) Deletion of the translocation domain abolishes the requirement for the chaperone for secretion. (D) In the absence of the chaperone and YopB/D, secretion is (partially) restored, indicating that the chaperone functions to protect premature interaction of the secreted Yop with YopB/D. See the text for further details.