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. 2022 Dec 8;614(7946):175–181. doi: 10.1038/s41586-022-05621-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — (a) Overall structure of yeast State 3. Black and red squares denote location of panels c and d, and g-j, respectively. (b) Overall structure of human State E. The black square denotes location of panels e and f. (c) Model of h31 bound by Rsm22, as observed in State 3. The grey arrow denotes relative movement of rRNA towards the decoding center due to subunit compaction after Rsm22 dissociation. (d) Same view as (c) in the structure of the N. crassa mitoribosome during translation (PDB:6YWY)⁶⁸, showing interactions of h31 with mRNA and the P-site tRNA. (e) Model of h31 bound by METTL17, as observed in State E. The grey arrow denotes relative movement of rRNA towards the decoding center due to subunit compaction after METTL17 dissociation. (f) Same view as (e) in the structure of the H. sapiens mitoribosome during translation bound to A, P, and E-site tRNAs (PDB:6ZSG)⁴⁰, showing interactions of h31 with mRNA and the P-site tRNA. In panels c-f, models are aligned on h31. (g–j) Timeline of yeast States 1–3 and the mature structure (PDB:5MRC)¹⁹ with associated map gaussian filtered at 1.4 standard deviations overlaid. Note absence of h45 in State 1 and mS38 in assembly intermediates States 1–3.