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. 2022 Dec 8;614(7946):175–181. doi: 10.1038/s41586-022-05621-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — (a–c) Models of METTL17, Rsm22, and SAF1 (Rsm22 in T. brucei, PDB:6SGB)¹⁵ respectively, with associated rRNA elements (top). Below, cryo-EM densities and models for ligands and their binding sites associated with each assembly factor (for T. brucei, map is EMD-10180, and empty density was originally modeled as a Zn²⁺)¹⁵. (d,e) Ordering of yeast mitoribosomal protein elements (shown as cartoon) in the head domain induced upon Rsm22 dissociation and head compaction. Peptides which become ordered between State 3 and the mature structure are colored in a darker shade. Additional protein and RNA components are shown as transparent surfaces. Mature structure derived from PDB:5MRC¹⁹. Models of RNA omitted for clarity. (f,g) Ordering of human mitoribosomal protein elements (shown as cartoon) in the head domain induced upon METTL17 dissociation and head compaction. Peptides which become ordered between State E and the mature structure are colored in a darker shade. Additional protein and RNA components are shown as transparent surfaces. Mature structure derived from PDB:6RW4⁶⁹. Previously ordered RNA omitted for clarity in mature structures.