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. 2022 Dec 8;614(7946):175–181. doi: 10.1038/s41586-022-05621-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, Model of the architecture around the rRNA 3′ end in human state B, illustrating binding of the 3′ end by ERAL1 and pre-recruitment of bS21m. The arrows highlight platform compaction that occurs between states B and C. b, Model of the architecture around the rRNA 3′ end in human state C, showing repositioning of the 3′ end via RBFA binding and recruitment of a uS11m–h23 module through bS21m. c, Model of the platform architecture in yeast state 1, before backpack and 3′ rRNA incorporation via the backpack. rRNA h45 is not yet incorporated into the particle, and the arrow highlights platform compaction that occurs between states 1 and 2. d, Model of the platform architecture in yeast state 2, after backpack docking and stabilization of 3′ rRNA. In parts a–d, conserved protein and rRNA elements share the same colours. e, Side view of the platform region rRNA in human state B. The arrows show movement of rRNA elements occurring between states B and C. f, Side view of the platform region rRNA in human state C, revealing compaction of the region, h23 binding and accommodation of NAD. g, Side view of the platform region rRNA in yeast state 1. The arrows show movement of rRNA elements occurring between states 1 and 2. h, Side view of the platform region rRNA in yeast state 2, revealing compaction of the region and ordering of rRNA h23, h24 and h45.