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. 2023 Jan 5;24(2):295–308. doi: 10.1038/s41590-022-01386-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — Shown is a heatmap displaying the top 20 up- and downregulated genes (by order of significance) of the transcriptome following stimulation of human Th17 cells with anti-CD3 and anti-CD28mAbs for 5 days in the presence (proinflammatory) or absence (anti-inflammatory) of exogenous IL-1β. The samples and genes were clustered according to the pattern of expression using k-means clustering.