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. 2023 Jan 5;24(2):295–308. doi: 10.1038/s41590-022-01386-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a, Locations of RORα and ROR-γt consensus binding sites in the regulatory region of IL1A. Binding sites were predicted using the JASPAR2022 database (Castro-Mondragon JA et al., Nucleic Acids Res 2022) and annotated with the UCSC genome browser (assembly hg38) (Kent WJ et al., Genome Res 2002). The quality cutoff was set at 400 (this score indicates a p value of p = 1*10- (score/100)). ENCODE tracks for histone marks were used to indicate the bona fide IL1A regulatory region (chr2:112,781,072-112,786,251) (Rosenbloom KR et al., Nucleic Acids Res 2013). b, Alignment of the RORα and RORγt consensus binding motif with the predicted binding sites in the IL1A enhancer RORα-IL1A.1 (chr2:112784300-112784309), RORα-IL1A.2 (chr2:112782834-112782843); RORγt-IL1A.1 (chr2:112,782,077-112,782,088); RORγt-IL1A.2 (chr2:112,784,298-112,784,309) and established binding sites in the IL17A enhancer RORα-IL17A.1 (chr6:52181117-52181130), RORα-IL17A.2 (chr6:52180979-52180992) and RORγt-IL17A.1 (chr6:52181118-52181129) (Wang X et al., Immunity. 2012). Scores for individual sites are indicated.