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. 2023 Jan 25;614(7946):153–159. doi: 10.1038/s41586-022-05641-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — Illustration of a selected set of functions (highlighted in red) for targeted data inspection and analysis implemented in the MitCOM Profile Viewer (https://www3.cmbi.umcn.nl/cedar/browse/experiments/CRX36 or, with extended functions, at https://www.complexomics.org/datasets/mitcom). The features include profile visualization and inspection of quantification details, as well as custom-defined MitCOM-wide Pearson correlation analysis for searching constituents of protein complexes. a, adjustable Gaussian smoothing of displayed abundance–mass profiles; b, inspection of peptide details used for protein quantification (i.e. underlying the selected datapoint) and generation of the abundance–mass profile(s); c, correlation analysis tool. A region of interest is targeted (‘target peak’) within the profile of a selected protein (left). Correlation analysis is started by clicking the “correlation” tab that opens a range-selection panel in which left and right boundaries of the target peak can be set by dragging the range-slider handles. Simultaneously, a list of 20 proteins exhibiting the highest Pearson correlation with the selected target peak segment is displayed (right, calculation in real time); d, normalization of selected sets of proteins to their maximum. A help page with detailed user instructions is available on the Viewer’s main window.