Table 4.

Treatments based on anatomical uveitis classification

Anterior uveitis	• Topical corticosteroid drops: 1% prednisolone acetate, 0.1% dexamethasone • Hourly dosing and reduce on improvement (generally treat for several weeks) • Possibly also mydriatic drop (ciliary spasm) • Monitor IOP (may require BB or CAI drop) and taper dose before stopping • Weaker active substance in steroid responders
Intermediate uveitis	• If macular oedema/pronounced vitritis: treat intermediate uveitis with systemic corticosteroids • In acute stage: oral corticosteroid, with either:  • Prednisolone equivalent, 1 mg/kg body weight  • IV corticosteroids (where necessary): methylprednisilone 10–30 mg/kg body weight, for 3 days (max daily dose is 1 g), for approximately 6–12 weeks; taper to a maintenance dose of 0.1 mg/kg body weight if required (taper for withdrawal). Higher dose/longer taper may be justified • Immune-modulating agents (DMARDS) in certain cases • Where corticosteroid therapy is C/I, steroid IVT • PRP for retinal neovascularisation or significant peripheral retinal capillary non-perfusion/ischaemia not advised unless non-clearing vitreous haemorrhage • Vitrectomy not advised unless vitreous haemorrhage
Posterior uveitis/non-occlusive/occlusive vasculitis	• In acute stage: oral corticosteroid, either:  • Prednisolone equivalent, 1 mg/kg body weight  • IV corticosteroids (methylprednisilone 10–30 mg/kg body weight, for 3 days (max daily dose is 1 g), for approx. 6–12 weeks; taper to a maintenance dose of 0.1 mg/kg body weight if required (taper for withdrawal). Higher dose/longer taper may be justified • Immune-modulating agents (DMARDS) in certain cases • Where corticosteroid therapy is C/I, steroid IVT • PRP for retinal neovascularisation or significant peripheral retinal capillary non-perfusion/ischaemia not advised unless non-clearing vitreous haemorrhage • Vitrectomy not advised unless vitreous haemorrhage

Abbreviations: BB, beta blocker eye drop; CAI, carbonic anhydrase drop; C/I, contraindicated; DMARDS, IOP, intraocular pressure; IV, intravenous; IVT, intravitreal; PRP, pan-retinal photocoagulation