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. 2023 Jan 27;28(1):1. doi: 10.1007/s10911-023-09528-y

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Organized hyaluronan-rich septa are deposited throughout the developing mammary gland. Immunofluorescence microscopy for hyaluronic acid binding protein (HABP; green) and DAPI nuclear stain alongside serial hematoxylin and eosin- stained images identifying key hyaluronan (HA) structures within mammary glands of virgin/nulliparous (A), pregnant (B), and involuting (C) BALB/c mice. HA extends throughout the mammary fat pad (IF images), dividing the gland into distinct lobules and encasing it in a fibrous capsule (inserts). Arrows highlight epithelial buds enveloped by HA-rich septa. Asterisks highlight adipocytes with a prominent pericellular HA coat. Whole-gland images were acquired on Leica DM6000B (IF) and DM5500B (H&E) microscopes at 100× magnification and stitched together via the LAS V3.8 software. Inserts were acquired on Leica DM6000B (IF) and DM5500B (H&E) microscopes at 200× magnification. Scale bars represent 100 µM