FIG. 8.

Model for termination of RC replication based on results from Novick’s laboratory (140, 141, 255–257). Nucleophilic attacks exerted by the OH groups of the Tyr residue of Rep (Y) or by 3′-OH groups of the DNA (OH) are indicated by arrows. Solid lines, parental DNA; broken lines, newly synthesized DNA. The thick solid line indicates the nucleotides that are newly synthesized past the reconstituted dso and that will remain covalently bound to the Rep protein to generate a Rep/Rep* inactive dimer. The two subunits of the RepC dimer are differently depicted.