Table 2.
Echocardiography parameters
| Characteristics | Acromegaly patients (n = 129) |
Healthy controls (n = 80) |
Newly diagnosed acromegaly patients (n = 27) |
Uncontrolled Acromegaly (n = 53) |
Controlled Acromegaly (n = 49) |
Acromegaly patients vs. healthy controls P-value |
Group comparison P-value |
|---|---|---|---|---|---|---|---|
| Ao. Asc. (mm) | 33.7 ± 3.4 | 32.7 ± 2.8 | 34.4 ± 1.8 | 33.1 ± 3.8 | 33.8 ± 3.2 | NS |
<0.007c NSa,b,d,e,f |
| LAVI (ml/m2) | 38.4 ± 7.2 | 29.1 ± 6.1 | 39.2 ± 6.8 | 36.9 ± 6.5 | 32.4 ± 5.2 | <0.001 |
<0.001c,e 0.018b 0.042d NSa,f |
| LVEDd (mm) | 50.5 ± 5.8 | 48.5 ± 2.2 | 53.7 ± 9.4 | 51.1 ± 4.0 | 48.6 ± 3.5 | NS |
<0.001c 0.006b NSa,f,d,e |
| RVEDd (mm) | 32.8 ± 3.8 | 31.4 ± 2.3 | 31.2 ± 3.9 | 31.7 ± 2.6 | 32.4 ± 2.9 | NS | NS |
| IVSDd (mm) | 12.4 ± 2.1 | 10.1 ± 1.0 | 13.5 ± 2.3 | 13.2 ± 1.7 | 10.9 ± 1.2 | <0.001 |
<0.001b,c,d,e,f NSa |
| PWDd (mm) | 11.6 ± 2.0 | 9.5 ± 1.0 | 13 ± 2.5 | 12.3 ± 1.5 | 10.2 ± 1.1 | <0.001 |
<0.001b,c,d,e,f NSa |
| LVM (g) | 248 ± 108 | 159 ± 28 | 324 ± 174 | 268 ± 71 | 185 ± 37 | <0.001 |
<0.001b,c,d,e,f NSa |
| LVMI (g/m2) | 123 ± 45 | 83 ± 16 | 154 ± 72 | 133 ± 29 | 96 ± 19 | <0.001 |
<0.001b,c,d,e,f NSa |
| LVH (%) | 67% | 18% | 81% | 83% | 43% | <0.001 |
<0.00b,c,d,e,f NSa |
| RWT > 0.42 (%) | 78 | 35 | 93 | 89 | 73 | <0.001 |
<0.001b,c,d,e 0.039f NSa |
| LVEF (%) | 58 ± 6 | 57 ± 3 | 54 ± 10 | 58 ± 5 | 59 ± 3 | NS |
0.039b NSa,c,d,e,f |
| E/E´ | 10.9 ± 3.62 | 9.2 ± 3.11 | 11.0 ± .5.46 | 10.4 ± .4.35 | 9.6 ± 3.94 | 0.003 |
0.012c 0.029b 0.038e NSa,d,f |
| E/A | 0.95 ± 0.4 | 1.15 ± 0.3 | 0.9 ± 0.35 | 1.0 ± 0.3 | 1.10 ± 0.5 | 0.001 |
0.008c 0.027b NSa,d,e,f |
| TAPSE (mm) | 22.2 ± 2.9 | 22.5 ± 1.1 | 22.3 ± 2.6 | 22.1 ± 3.2 | 22.3 ± 2.7 | NS | NS |
| Valvopathy (%) | 43 | 10 | 67 | 38 | 35 | <0.001 |
<0.001c,e,f 0.007b 0.014a NSd |
Data is presented as mean ±standard deviation (SD) and as percentage
Level of significance was set at *p ≤ 0.05
Ao. Asc. ascending aorta, LAVI left atrial volume index, LVEDd left ventricular end-diastolic parameter, RVEDd right ventricular end-diastolic parameter, IVSDd interventricular septum diastolic diameter, PWDd posterior wall diastolic diameter, LVM left ventricular mass, LVMI left ventricular mass index, LVH left ventricle hypertrophy, RWT relative wall thickness, LVEF left ventricular ejection fraction, E/E´ mitral E-wave velocity divided by mitral annular velocity, E/A mitral E-wave divided by mitral A-wave velocity, TAPSE tricuspid annular plane systolic excursion
aNewly diagnosed acromegaly patients vs. uncontrolled
bNewly diagnosed acromegaly patients vs. controlled
cNewly diagnosed acromegaly vs. healthy controls
dUncontrolled vs. controlled
eUncontrolled vs. healthy controls
fControlled vs. healthy controls