Figure 5. Microglia activation in the cognitively impaired marmoset.
Confocal images of microglial cells in CA1 (A) and layer 3 of dlPFC (B,C). Top panels show merged images of the respective single channels below each column: Iba-1 (green); CD68 (red); and DAPI (blue). In yellow (top panels A-C), CD68-expressing lysosomes within microglial cells. (D) Box-and-whiskers plots showing CD68-expressing lysosome content within Iba-1-immunoreactive microglial cells in the layer 3 of dlPFC and CA1. (E) Quantification of Iba-1 expressing microglia in layer 3 of dlPFC and CA1. *, p < 0.05. Scale bar=10 μm.