TABLE 2.

Results of the MR study testing causal association between systemic inflammatory regulators and risk of ACLF.

Cytokines	Number of SNPs	Beta	Or (95% CI)	P	P For heterogeneity test	P For MR-Egger intercept	P For MR-PRESSO (0 outliers)
Stem cell factor
Inverse variance weighted	9	−0.722	0.486 (0.264–0.892)	0.020	0.501	0.790	0.179
MR Egger	9	−0.555	0.574 (0.151–2.178)	0.441	0.403
Weighted median	9	−0.503	0.605 (0.263–1.392)	0.237
IL-13
Inverse variance weighted	12	0.400	1.492 (1.111–1.204)	0.008	0.862	0.287	0.081
MR Egger	12	0.154	1.167 (0.693–1.694)	0.574	0.897
Weighted median	12	0.288	1.333 (0.923–1.926)	0.125

Cytokines	Number of SNPs	Beta	Or (95% CI)	P	P For heterogeneity test	P For MR-Egger intercept	P For MR-PRESSO
Basic fibroblast growth factor
Inverse variance weighted	5	−1.130	0.323 (0.107–0.972)	0.044	0.649	0.900	0.105
MR Egger	5	−0.799	0.450 (0.004–56.475)	0.767	0.483
Weighted median	5	−1.558	0.211 (0.051–0.871)	0.031
Macrophage inflammatory protein-1α (CCL3)
Inverse variance weighted	8	0.626	1.870 (1.077–3.247)	0.026	0.848	0.964	0.010
MR Egger	8	0.592	1.807 (0.398–8.203)	0.473	0.760
Weighted median	8	0.443	1.558 (0.759–3.198)	0.227