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. 2023 Feb 2;9:40. doi: 10.1038/s41420-023-01315-2

Fig. 3. CDC7 inhibitor XL413 shows synergistic effect with chemo-treatment in resistant SCLC cells.

Fig. 3

A IC50 of XL413 in H69-AR(left) and H446-DDP(right) are 416.8 μM and 681.3 μM. B Comparison of DDP IC50 with or without XL413 in H69-AR(left, XL413 50 μM) and H446-DDP(right, 80 μM). C Cell viability matrices of DDP and XL413 in H69-AR(left) and the HSA model heatmap(right). D Cell viability matrices of DDP and XL413 in H446-DDP(left) and the HSA model heatmap(right). E Cell viability of H69-AR treated with negative control, XL413(50 μM), DDP, and VP16(1 μg/ml, 100 μg/ml) and combined treatment using CCK-8 assay. F Cell viability of H446-DDP treated with negative control, XL413(80 μM), DDP, and VP16(5 μg/ml, 80 μg/ml) and combined treatment using CCK assay.