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. 2023 Feb 2;9:40. doi: 10.1038/s41420-023-01315-2

Fig. 5. XL413 and chemo-treatment induce G1/S arrest in resistant SCLC cells.

Fig. 5

A Cell cycle flow cytometric analyses of H69-AR treated with negative control, XL413(50 μM), DDP, and VP16 (1 μg/ml, 100 μg/ml) and combined treatment for 48 h. B Quantification of cell percentage for each cell cycle in (A) and two more independent experiments. C Cell cycle flow cytometric analysis of H446-DDP treated with negative control, XL413 (80 μM), DDP, and VP16 (5 μg/ml, 80 μg/ml) and combined treatment for 48 h. D Quantification of cell percentage for each cell cycle in B and two more independent experiments. Western blot analysis of phosphorylated Chk1, cyclin E1, cyclin D1, and GAPDH in H69-AR (E) and H446-DDP (F) treated with XL413 and chemo-treatment alone or combined treatment for 48 h.