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. 2023 Feb 2;9:40. doi: 10.1038/s41420-023-01315-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Images of H69-AR xenograft tumors after XL413 (20 mg/kg) and chemo-therapy (2.5 mg/kg DDP and 4 mg/kg VP16) alone or combined treatment. B Tumor volume curve of xenograft tumors. The arrow indicated the start of treatments. C Body weight curve of H69-AR xenograft mice. The arrow indicated the start of treatments. D Tumor weight scatter plot of H69-AR xenograft model. E Inhibition rate of XL413 and chemo-therapy alone or combined treatment calculated via PDX HDRA.