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. 2023 Jan 19;10:1121508. doi: 10.3389/fnut.2023.1121508

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Copyright © 2023 Mahanta, Komal, Samal, Bhoi, Dubey, Pradhan, Nekkanti, Gouda, Saini, Negi, Bhateja, Jat and Jeengar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representing use of silkworm pupae proteins in different function and physiological mechanisms. (A) Consumption of pupal protein is used as antibacterial agent as protein hydrlysate regulates GSH production activity, Expression of SOD and ROS reduction. (B) Pupal protein is used for reducing blood pressure by inhibiting Angiotensin I-converting enzyme by protein hydrolysate. (C) Pupal protein is used as antioxidant as it activate innate immunity and activate IL-6, IL-12, Cyclin, D1, CDK4. (D) Pupal protein is used as anticancer agent as protein hydrolysate activates ROS, Bax, P53 which cause apoptosis and also stop S- phase of cell division. (E) Pupal protein impact on decreasing blood lipids and sugar level as protein hydrolysate activate GLUT4, Acrp30, and Leptin.