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. 2023 Feb 1;14:535. doi: 10.1038/s41467-023-36265-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Heat maps of age-related reversible genes (ARRs) (moderated LFC > 1, s-value < 0.15, LFC batch <0.5). Left columns display the LFCs due to age (Aged T0–Young T0), engraftment (Young T21–Young T0), and the niche (Aged T21–Aged T0–LFC engraftment). The middle column displays the effect of ageing, using the mean of Young T0 samples as baseline. The right column displays the effect of the heterochronic niche, using the mean of Young T21 samples as baseline. b Heat maps of age-related reversible genes (ARRs) (moderated LFC > 1, s-value < 0.15, LFCbatch>0.5). Left columns display the LFCs due to age (Aged T0–Young T0), engraftment (Young T21–Young T0), and the niche (Aged T21–Aged T0–LFC engraftment). The middle column displays the effect of ageing, using the mean of Young T0 samples as baseline. The right column displays the effect of the heterochronic niche, using the mean of Young T21 samples as baseline. c Integrative Genomics Viewer (IGV) tracks for select representative ARIs and ARRs d Scatterplot of the moderated LFCs of the effect of niche exposure vs the effect of age. Gray area represents the 95% confidence interval for the mean. e Pie charts showing the percentage of genes that are up, downregulated, or changed in in either direction in aging that are either reversible or irreversible by exposure to the young niche. Left and right groups of pie charts correspond to different threshold cutoffs for differential gene expression.