Fig. 2. A combined Manhattan plot of uterine leiomyomata (UL) associations in two sets of meta-analyses.

We conducted UL GWAS in FinnGen and, subsequently, two sets of meta-analyses with data from a previously published UL meta-analysis:¹² META-1 (top) was limited to the top 10,000 most significant variants from the previous study¹², and included up to 53,534 UL cases and 373,024 female controls whereas META-2 (bottom) was conducted genome-widely in 38,466 UL cases and 329,437 female controls. The purple colour denotes UL risk loci identified in META-1 that have not been described in prior studies, and the pink color indicates loci identified in META-2 that were not associated previously with UL risk in prior GWASs or META-1. Black and grey colours indicate odd and even chromosome numbers, respectively. The red dashed lines correspond to the threshold for genome-wide significance (p < 5 × 10⁻⁸).