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. 2022 Dec 17;122(2):269–278. doi: 10.1016/j.bpj.2022.12.020

Figure 5.

Figure 5

Aggregation mechanism of Aβ42 in the presence of subnucleus-sized LMWOs and nucleation-mediating HMWOs. Monomers are in equilibrium with LMWOs (3–6 monomeric units) and HMWOs (20–160 monomeric units). Either consolidation of HMWOs or formation of an elongation competent LMWO leads to the formation of a nucleus competent in monomer recruitment that initiates amyloid formation. LMWOs and then HMWOs dissolve upon aggravated monomer consumption through fibril elongation and secondary nucleation. To see this figure in color, go online.