Figure 3.

Results of reweighting the conformational ensembles generated with FM and CALVADOS against SAXS data. The ${\chi }_{\mathrm{r}}^2$ of the prior ensembles (before reweighting) are shown as partially transparent bars, while the ${\chi }_{\mathrm{r}}^2$ of the reweighted ensembles are shown as solid bars (blue for FM and red for CALVADOS). The horizontal black line delineates ${\chi }_{\mathrm{r}}^2=$ 1, that, given the use of scaled errors for experimental SAXS intensities (see materials and methods), denotes reweighted ensembles in good agreement with the experimental data and devoid of overfitting. To see this figure in color, go online.