Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 19;13:1051045. doi: 10.3389/fimmu.2022.1051045

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Bai, Wu, Zhu, Zhang, Chen, Su, Pan, Li, Yue, Xu, Xie, Tian, Zhao, Li, Hou, Wang, Fu, Xue, Jiang, Li, Xu, Tian, Zhou, Zhang and Bai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

mRNA-seq data reveal the altered AMPK/mTORC1 signaling in Vam6 ^+/- iNKT cells. (A) Heatmap displaying 3440 significantly dysregulated genes in Vam6 ^+/- iNKT cells in comparison with Vam6 ^+/+ iNKT cells after stimulation with CD1d-PBS57 tetramer for 4 hours. The significance threshold is fold change ≥ 2 and FDR ≤ 0.05. (B) Correlation plot displaying expression of genes in Vam6 ^+/- iNKT cells and in Vam6 ^+/+ iNKT cells. (C) KEGG pathway analysis showing pathways downregulated and upregulated in Vam6 ^+/- iNKT cells. Bars represent the number of differentially expressed genes contributing to each gene set. (D) GO term analysis showing pathways upregulated in Vam6 ^+/- iNKT cells. (E, F) Heatmaps showing expression of genes involved in mTORC1 pathway (E) and AMPK pathway (F) in Vam6 ^+/- iNKT cells and in Vam6 ^+/+ iNKT cells.