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. 2023 Jan 19;14:1088501. doi: 10.3389/fimmu.2023.1088501

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Copyright © 2023 Sun, Lin, He, Zhang, Zhou and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decoration of engineered OMVs with heterologous S. aureus antigens. (A) Schematic representation of the selection of the recombinant S. aureus antigen stEsxA, stSbi and stSpA. (B) Western blot analysis of OMVsc bond with heterologous recombinant S. aureus antigens by using an anti-His₆ primary antibody. The red arrow indicates the trOmpA-antigen conjugations and the black arrow indicates the trOmpA-SpyCather fusion protein.