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. 2023 Jan 19;13:1087689. doi: 10.3389/fimmu.2022.1087689

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Copyright © 2023 Luo, Zhou, Zhang, Zhang, Long, Lin, Yang, Duan, Yang, Yang, Che, Yang, Guo, Zi, Ouyang, Yang, Zeng and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anti-tumor activity of eNK-EXO-DDP in vitro. (A) Schematic diagram showing the preparation of eNK-EXO-DDP. (B) CCK-8 assay showing the cytotoxicity of eNK-EXO-DDP against SKOV3, COC1/DDP and OV-90 cells (n=3, mean ± SEM, **p< 0.01, ***p< 0.001). (C) Flow cytometry analysis of anti-proliferation activity of eNK-EXO-DDP against SKOV3 cells. (D) EdU assay result of anti-proliferation activity of eNK-EXO-DDP against SKOV3 cells, Scale bar=100 µm. (E) Cell cycle analysis of SKOV3 cells after eNK-EXO-DDP treatment by flow cytometry. (F) Apoptosis analysis of SKOV3 cells after eNK-EXO-DDP treatment by flow cytometry. (G) Statistical analysis of apoptosis rate is based on three experiments, mean ± SEM, *p< 0.05, **p< 0.01, ***p< 0.001. (H) Western blot analysis of PARP, cleaved PARP, cleaved caspase 3 and cleaved caspase 7 in SKOV3 and COC1/DDP cells after different treatments.