Table 2.
Multi-variate adjusted ORs (95% CIs) of NAFLD and MAFLD in relation to quartile increment of nine predictive indexes among participants in NHANES 2017-2018.
| Variables | Model 1 | p-Value | Model 2 | p-Value | Model 3 | p-Value |
|---|---|---|---|---|---|---|
| MAFLD | ||||||
| BMI | 9.925[4.677,21.063] | <0.001 | 10.986[5.317,22.698] | 0.001 | 10.847[5.195,22.650] | 0.008 |
| WC | 16.011[7.257,35.321] | <0.001 | 15.449[7.440,32.077] | <0.001 | 15.638[7.426,32.935] | 0.005 |
| VAI | 4.000[2.699,5.929] | <0.001 | 4.651[2.966,7.295] | 0.001 | 4.399[2.698,7.172] | 0.010 |
| LAP | 15.372[7.152,33.039] | <0.001 | 16.609[7.927,34.797] | <0.001 | 15.931[7.720,32.876] | 0.005 |
| WHtR | 11.323[6.324,20.277] | <0.001 | 15.005[8.052,27.964] | <0.001 | 15.399[8.214,28.870] | 0.003 |
| TyG | 6.178[3.958,9.644] | <0.001 | 5.901[3.825,9.102] | <0.001 | 5.768[3.608,9.223] | 0.005 |
| TyG-BMI | 16.132[6.316,41.202] | <0.001 | 17.196[7.193,41.110] | 0.001 | 17.118[7.165,40.895] | 0.008 |
| TyG-WC | 29.436[11.649,74.379] | <0.001 | 28.435[12.121,66.705] | <0.001 | 28.877[12.298,67.805] | 0.005 |
| TyG-WHtR | 19.412[9.256,40.710] | <0.001 | 26.863[12.417,58.115] | <0.001 | 27.798[12.960,59.623] | 0.003 |
| NAFLD | ||||||
| BMI | 5.775[3.145,10.603] | <0.001 | 6.047[3.315,11.032] | 0.001 | 5.806[3.106,10.851] | 0.012 |
| WC | 8.714[4.531,16.759] | <0.001 | 8.204[4.491,14.985] | <0.001 | 7.921[4.232,14.826] | 0.007 |
| VAI | 3.173[2.077,4.846] | <0.001 | 3.706[2.309,5.948] | 0.002 | 3.557[2.129,5.942] | 0.017 |
| LAP | 8.779[4.768,16.166] | <0.001 | 9.731[5.318,17.807] | <0.001 | 9.350[5.087,17.188] | 0.006 |
| WHtR | 6.234[3.883,10.008] | <0.001 | 7.939[4.797,13.140] | <0.001 | 7.767[4.584,13.160] | 0.005 |
| TyG | 4.997[3.262,7.656] | <0.001 | 4.896[3.164,7.577] | <0.001 | 4.826[2.962,7.861] | 0.008 |
| TyG-BMI | 8.178[4.005,16.699] | <0.001 | 8.278[4.199,16.321] | 0.001 | 8.113[4.084,16.116] | 0.009 |
| TyG-WC | 13.343[6.579,27.061] | <0.001 | 12.742[6.576,24.689] | <0.001 | 12.642[6.453,24.766] | 0.005 |
| TyG-WHtR | 9.329[5.363,16.227] | <0.001 | 12.202[6.830,21.798] | <0.001 | 12.283[6.782,22.245] | 0.004 |
MAFLD, metabolic dysfunction-associated fatty liver disease; NAFLD, non-alcoholic fatty liver disease; BMI, body mass index; WC, waist circumference; VAI, visceral adiposity index; LAP, lipid accumulation product; WHtR, waist-to-height ratio; TyG, triglyceride and glucose index. Model 1 included only independent variables; model 2 was additionally adjusted for gender, age, ethnicity, FIPR and education level; and model 3 was further adjusted for the disease history (hypertension, high cholesterol and diabetes).