Table 2.
Non‐coding RNA influenced by m6A and its function in cancers.
| Type | Name | Effect | Mechanisms |
|---|---|---|---|
| circRNA | circ0008399 | Promotes cell cisplatin resistance (BCA) | Up‐regulation of TNFAIP3 [159] |
| circ_104075 | Stimulates YAP‐dependent tumorigenesis (HCC) | Up‐regulation of YAP by absorbing miR‐582‐3p [215] | |
| circDLC1 | Inhibits MMP1‐mediated cancer progression (LC) | Interaction with HuR and down‐regulation of MMP1 [41] | |
| miRNA | miR‐25‐3p | Promotes cancer progression (PRAD) | Activation of AKT‐p70S6K signaling [147] |
| miR‐96 | Promotes cancer occurrence and progression (CRC) | Regulation of AMPKα2‐FTO‐m6A/MYC axis [216] | |
| miR‐143‐3p | Promotes lung cancer brain metastasis (LC) | Inhibition of VASH1 [127] | |
| miR‐320b | Inhibits cancer angiogenesis and tumor growth (LC) | Inhibition of HNF4G, IGF2BP2 and TK1 [217] | |
| miR‐135 | Inhibits cell epithelial–mesenchymal transition (BC) | Regulation of miR‐135/ZNF217/METTL3/NANOG axis [218] | |
| lncRNA | FAM225A | Promotes tumorigenesis and metastasis (NPC) | Adsorption of miR‐590‐3p and miR‐1275 and up‐regulation of ITGB3 [133] |
| LCAT3 | Promotes tumorigenesis (LC) | Activation of c‐MYC [219] | |
| LINC00278 | Inhibits cell apoptosis (ESCC) | Down‐regulation of YY1BM [220] | |
| GAS5 | Inhibits cancer progression (CRC) | Phosphorylation and degradation of YAP [221] | |
| rRNA | 28S | Inhibits cell proliferation (HCC) | Reduction of global translation [7] |
| 18S | Promotes cell proliferation (BC) | Promotion of translation initiation [39] |