TABLE 1.

General patient characteristics.

		N	Patients without ITM n = 288	Patients with ITM n = 94	P-value
Gender	Male	119	86 (30%)	33 (35%)	0.340
	Female	263	202 (70%)	61 (65%)
	Male-to-female ratio		1:2.4	1:1.9
Age (years)	Mean		53	62	<0.001
	Median		53	65
	Range		16–97	28–96
Histologic subtype	SSM	226	198 (69%)	28 (30%)	<0.001
	NM	62	38 (13%)	24 (26%)
	ALM	43	25 (9%)	18 (18%)
	NOS	35	27 (22%)	21 (22%)
	MUP	3	–	3 (3%)
Tumor thickness (mm)	Mean		1.4	3.5	<0.001
	Median		0.9	1.9
	Range		0.1–35.0	0.2–15.0
	Unknown		–	8 (8%)
Ulceration*	Present	81	44 (15%)	37 (46%)	<0.001
	Absent	288	244 (85%)	44 (54%)
Location of melanoma**	Foot	75	49 (17%)	26 (28%)	<0.001
	Lower leg	159	112 (39%)	47 (52%)
	Thigh	145	127 (44%)	18 (20%)
Number of ITM	1–5			34 (36%)
	6–10			18 (19%)
	11–20			14 (15%)
	>20			15 (16%)
	Unknown			13 (14%)
ITM localization**	Only proximal of melanoma			46 (80%)
	Distal and proximal of melanoma			9 (20%)
Time between melanoma and first ITM [months]	Mean			34
	Median			19
	Range			0–244
Images (including MUP)	3D photography			29 (31%)
	Conventional photography			32 (34%)
	No evaluable images available			33 (35%)

ITM, in-transit metastasis; SSM, superficial spreading melanoma; NM, nodular melanoma; ALM, acral lentiginous melanoma; NOS, not otherwise specified; MUP, melanoma of unknown primary; 3D, three-dimensional.

*Ulceration status was unknown (n = 10) or a MUP was present (n = 3).

**MUP (n = 3). Characteristics of patients with melanoma of the lower extremity with in-transit metastases (n = 94) compared to patients without recurrence of melanoma (n = 288) with regard to primary melanoma and in-transit metastases.