TABLE 2.

Multivariate logistic regression analysis of risk factors for in-transit metastases of melanoma of the lower extremity.

		Univariate analysis			Multivariate analysis
		Hazard ratio	95% CI	P -value	Hazard ratio	95% CI	P -value
Age (years)	<55	1.0			1.0
	≥55	2.5	1.4–4.3	<0.001	1.5	0.8–2.8	0.214
Histologic subtype*	SSM	1.0			1.0
	NM	4.7	2.4–9.0	<0.001	2.6	1.2–5.5	0.011
	ALM	4.6	2.1–9.8	<0.001	2.7	0.8–9.2	0.121
	NOS	2.1	0.8–5.4	0.111	1.7	0.6–4.9	0.296
Tumor thickness (mm)*	<1.0	1.0			1.0
	≥1.0	10.5	4.6–23.6	<0.001	5.7	2.3–13.9	<0.001
Ulceration*	Present	1.00			1.0
	Absent	5.1	2.9–8.9	<0.001	2.1	1.1–4.0	0.032
Location of melanoma	Foot	1.0			1.0
	Lower leg	0.8	0.4–1.4	0.374	1.8	0.6–5.0	0.272
	Thigh	0.3	0.1–0.6	<0.001	0.6	0.2–1.8	0.349

CI, confidence interval; SSM, superficial spreading melanoma; NM, nodular melanoma; ALM, acral lentiginous melanoma; NOS, not otherwise specified; MUP, melanoma of unknown primary.

*Missing values: histologic subtype n = 17, tumor thickness n = 8, ulceration n = 13. Multivariate logistic regression analysis of significant variables in the univariate analysis was performed in a full dataset of 359 patients with melanoma of the lower extremity.

Bold values represent the p < 0.05.