Table 4.
New studies on adverse effects on broilers chickens which have become available since the 2017 Opinion (EFSA CONTAM Panel, 2017a) and considered not useful for the derivation of an RP
| N$/group, breed gender | Dosage and duration (mg/kg feed or mg/kg bw) | Reason for exclusion | References |
|---|---|---|---|
| 112, ROS 308 broilers chickens | 0, 5 mg DON/kg feed for 15 days | Refers to performance data included in previously reviewed paper from 2015. | Antonissen et al., 2017 |
|
80, 81‐day old Hubbard female chickens |
0, 10 mg DON/kg feed for 35 days | Animals were dosed twice the current guidance level ➔ not useful for the scope of the present mandate. | Azizi et al., 2021 |
|
208, black‐feathered Taiwan country chickens |
0, 2, 5 and 10 mg/kg of DON for 3, 10, 16 weeks | Inconsistency in the study results: animals fed the 5 mg/kg feed gained more weight than those fed the 2 mg/kg feed. | Chen et al., 2017 |
|
80, 1‐day‐old ROSS 308 broiler chicks |
0, 2.5, 5, 10 mg DON/kg feed for 5 weeks | Elaboration of data collected in Lucke et al., 2017 (below). Unsuitable due to DON effects quadratically related to increasing concentrations. | Keçi et al., 2019 |
|
640, 240 22‐day‐old Ross 308 broiler chickens (metabolism trials) and 400 7‐day‐old Ross 308 broiler chicks (growth trials) |
0, 10, 20% inclusion of DON | Inconsistency in the study design and results (observed effects related to the level of DDGS* rather than to DON. No analytical results for the complete diet) | Kim et al., 2021 |
|
160, Ross 308 broilers |
0, 2.5, 5, and 10 mg/kg FOR 3 and 5 weeks | Unsuitable due to high uncertainty on unreported sex ratio between groups and quadratic effect on LWG, resulting in a large uncertainty on FI. | Lucke et al., 2017 |
|
40, 1‐day‐old ROSS 308 broilers |
0, 2.5, 5 and 10 mg/kg for 5 weeks | Elaboration of data collected in Lucke et al. (2017). Unsuitable due to DON effects quadratically related do increasing concentrations. | Lucke et al., 2018a |
|
40, 1‐day‐old ROSS 308 broilers |
0, 2.5, 5 and 10 mg/kg for 5 weeks | Elaboration of data collected in Lucke et al. (2017). Unsuitable due to DON effects quadratically related to increasing concentrations. | Lucke et al., 2018b |
|
28, Ross PM3 male broiler chickens |
0 and 5 mg/kg for 35 days | One concentration and no effects | Metayer et al., 2017 |
|
48, 3‐week‐old Cobb 540 cockerels |
0, 16.12 mg/kg for 48 h | Unsuitable study design (48 h treatment only) | Nakade et al., 2018 |
|
60, 1‐ and 3‐week‐old Cobb 540 cockerels |
4.86 mg DON and 1.39 mg 15‐ADON/kg for 4, 8, 12, 16, 20 and 24 h | Unsuitable study design (24 h treatment only) | Pelyhe et al., 2018 |
|
9, 1‐day‐old male Ross 308 broiler chicks |
10 mg/kg for 5 weeks | Unsuitable study due to single (high) concentration, few experimental animals | Sager et al., 2018 |
|
368, 1‐day‐old male Ross 308 broilers |
0.9 mg/kg and 2.3 mg/kg for 14 and 28 days | Unsuitable study design (no control group) | Santos and Van Eerden, 2021 |
|
40, Ross 308 broiler chickens |
0, 0.05 mg/kg bw for 36 days | Unsuitable study due to high uncertainty on experimental design and information provided in the paper | Solcan et al., 2017 |
|
120, 1‐day‐old male Hailan chickens |
0, 0.27, 1.68 and 12.21 mg/kg−1 DON for 36 days | Unsuitable study due to unclear endpoint (adverse clinical effects without detailer description) | Wang et al., 2018 |
Distiller's dried grains with solubles.