A list of marine-derived antimalarial alkaloids showing their IC₅₀ against various strains of Plasmodium sp., chemical structure and biogenic source^a.

Compound	Antiplasmodial activity (IC50 value)	Structure	Source	Marine class	Ref.
Manzamine A (1)	W2 = 0.015 μM D6 = 0.0082 μM		Okinawan Haliclona	Sponge	27
8-Hydroxymanzamine (2)	W2 = 0.014 μM D6 = 0.010 μM			Sponge	27
Manzamine F (3)	W2 = 2.93 μM 6 = 1.34 μM			Sponge	27
6-Hydroxymanzamine (4)	W2 = 1.5 μM D6 = 1.36 μM			Sponge	27
Neo-kauluamine (5)	D6 = 1.46 μM W2 = 2.41 μM		Indo-pacific sponge	Sponge	28
12,34-Oxamanzamine A (6)	D6 = 8.97 μM			Sponge	28
Zamamidine A (7)	0.0008 to 0.016 μM		Amphimedon sp.	Sponge	35
Zamamidine B (8)				Sponge
Zamamidine C (9)				Sponge
Zamamidine D (10)				Sponge
Homofascaplysin (11)	K1 = 0.04 μM NF54 = 0.07 μM		Hyrtios sponge	Sponge	38
Marinacarboline A (12) Marinacarboline B (13) Marinacarboline C (14)	3D7 and Dd2 IC50 from 1.92 to 36.03 μM		Marinactinospora thermotolerans	Actinomycete bacteria	39
Marinacarboline D (15)
13-N-Demethyl-methylpendolmycin (16) methylpendolmycin-14-O-α-glucoside (17)	3D7 = 20.75 and 10.43 μM Dd2 = 18.67 and 5.03 μM		Marinactinospora thermotolerans	Actinomycete bacteria	38
Crambescidin 800 (18)	3D7 = 0.16 μM FCR3 = 0.24 μM		Monanchora unguiculate	Sponge	39 and 40
Crambescidin 359 (19) crambescidin acid (20)	3D7 = 20.75 and 10.43 μM Dd2 = 18.67 and 5.03 μM
Fromiamycalin (21)	3D7 = 0.24 μM
Unguiculin A (22)	3D7 = 12.86 μM
Ptilomycalins E (23) Ptilomycalins F (24) Ptilomycalins G (25)	3D7 = 0.35, 0.23, and 0.46 μM				41
Ptilomycalins H (26)	3D7 = 0.46 μM
Opacaline B (27) Opacaline C (28)	K1 range of 2.5–14 μM		Pseudodistoma opacum	New Zealand ascidian	42
Didemnidine A (29) Didemnidine B (30)	K1 = 0.047 μM		Ascidian Didemnum sp.	Marine tunicate	43
Salinosporamide A (31)	3D7 = 11.4 nM FCB = 19.6 nM		Salinispora tropica	Marine actinomycete bacteria	44
Psammaplysin H (32) Psammaplysin F (33) Psammaplysin G (34)	3D7 = 0.41, 1.92, and 5.22 μM		Aplysinella strongylata	Sponge	52
Ceratinadin E (35)	K1 = 0.9 μM		Okinawan Pseudoceratina	Sponge	54
Ceratinadin F (36)	K1 > 8.16 μM
Tsitsikammamine C (37)	3D7 = 13 nM Dd2 = 18 nM		Zyzzya sp.	Sponge	55
Makaluvamine J (38)	3D7 = 25 nM Dd2 = 22 nM				55
Makaluvamine G (39) Makaluvamine L (40)	3D7 = 36, 40 nM Dd2 = 39, 21 nM
Makaluvamine K (41)	3D7 = 396 nM Dd2 = 300 nM
Damirone A (42) Damirone B (43)	3D7 = 1880 Dd2 = 360 nM
Dihydrodiscorhabdin B (44)	D6 = 0.17 μM W2 = 0.13 μM		Latrunculia sp.	Sponge	56
Discorhabdin Y (45)	EC50 = 0.5 μM
Discorhabdin A (46)	D6 = 0.05 μM W2 = 0.05 μM				56
Discorhabdin C (47)	D6 = 2.8 μM W2 = 2.0 μM
Discorhabdin E (48)	W2 = 0.2 μM
Discorhabdin L (49)	W2 = 0.13 μM
Dihydrodiscorhabdin C (50)	D6 = 0.17 μM W2 = 0.13 μM
Girolline (51)	FCM29 = 0.13 μM		Cymbastela cantharella	Sponge	58
Thiaplakortone A (52)	3D7 = 51 Dd2 = 6.6 nM		Plakortis lita	Sponge	59
Thiaplakortone B (53)	3D7 = 650 Dd2 = 92 nM
Thiaplakortone C (54)	3D7 = 309 Dd2 = 171 nM
Thiaplakortone D (55)	3D7 = 279 Dd2 = 159 nM
Monamphilectine A (56)	W2 = 600 nM		Hymeniacidon sp.	Sponge	60
Agelasine J (57)	FcB1 = 6.6 μM		Agelas mauritiana	Sponge	61
Agelasine K (58)	FcB1 = 8.3 μM
Agelasine L (59)	FcB1 = 18 μM
Netamine G (60)	NA		Biemna laboutei	Sponge	62
Netamine H (61)
Netamine I (62)
Netamine J (63)
Netamine K (64)	(64) IC50 = 2.4 μM NA for the other compounds (65–67)
Netamine L (65)
Netamine M (66)
Netamine N (67)			Biemna laboutei	Sponge

^aNA:not available.