A list of marine-derived peptides and depsipeptides antimalarial drugs showing their IC₅₀ against various strains of Plasmodium sp., chemical structure and biogenic source^a.

Compound	Antiplasmodial activity (IC50 value)	Structure	Source	Marine class	Ref.
Balgacyclamide A (139)	K1 IC50 = of 9.0 and 8.2 μM, respectively		Microcystis aeruginosa	Cyanobacteria	122
Balgacyclamide B (140)
Balgacyclamide C (141)	NA
Aerucyclamide A (142)	K1 = 5.0, 0.7, 2.3, and 6.3 μM, respectively		Microcystis aeruginosa	Cyanobacteria	123 and 124
Aerucyclamide B (143)
Aerucyclamide C (144)
Aerucyclamide D (145)
Mollamide B (146)	D6 = 0.0029 μM W2 = 0.003 μM		Didemnum mole	Tunicate	125
Dolastatin 10 (147)	FCH5·C2 = 0.1 nM		Symploca sp.	Cyanobacteria	126 and 127
Dragonamide A (148)	3D7 = 7.7, 7.0, and 6.0 μM		Moorea producens	Cyanobacteria	128 and 129
Dragonamide B (149)
Dragomabin (150)
Carmabin A (151)	3D7 = 4.3 μM
Malyngamide X (152)	K1 ED50 = 5.44 μM		Bursatella leachii	Thai sea hare	130
Romidepsin (153)	∼150 nM		Violaceous sp	Cyanobacteria	131 and 132
Venturamide A (154)	W2 = 8.2 and 5.2 μM		Oscillatoria sp.	Cyanobacteria	133
Venturamide B (155)
Companeramide A (156)	D6 = 570 and 220 nM Dd2 = 1000 and 230 nM		Panamanian marine Cyanobacterium sp.	Cyanobacteria	134
Companeramide B (157)
Lagunamide A (158)	NF54 = 190, 910 and 290 nM		Lyngbya majuscule	Cyanobacteria	135 and 136
Lagunamide B (159)
Lagunamide C (160)
Mollemycin A (161)	3D7 = 7 nM Dd2: 9 nM		Streptomyces sp.	Marine actinomycetes	137
Symplocamide A (162)	W2 = 0.95 μM		Streptomyces ballenaensis and S. bangulaensis	Marine actinomycetes	138 and 139
Actinoramide A (163)	HB3 = 190 nM Cp250 = 210 nM Dd2 = 220 nM 7G8 = 160 nM GB4 = 340 nM				140
Symplostatin 4 (164)	3D7 ED50 = 74 nM		Symploca sp	Cyanobacteria	141 and 142
Gallinamide A (165)	3D7 = 50.1 ± 7.6 nM W2 = 8.4 μM		Schizothrix sp.	Cyanobacteria	144
Viridamide A (166)	W2 = 5.8 μM		Oscillatoria nigro-viridis	Cyanobacteria	145

^aNA: not available.