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. 2023 Feb 2;13(7):4436–4475. doi: 10.1039/d2ra07977a

A list of marine-derived phosphotriesters, polyether, and steroidal glycosides antimalarial drugs showing their IC50 against various strains of Plasmodium sp., chemical structure and biogenic sourcea.

Compound Antiplasmodial activity (IC50 value) Structure Source Marine class Ref.
Salinipostin A (167) Salinipostin F (172) Salinipostin I (175) W2 = 50, 266, and 126 nM graphic file with name d2ra07977a-u143.jpg Salinospora sp. Marine actinomycetes 146
Salinipostin B (168) Salinipostin D (170) Salinipostin G (173) Salinipostin J (176) W2 = 139, 82, 1.52 μM, respectively (176) NA graphic file with name d2ra07977a-u144.jpg
Salinipostin C (169) Salinipostin E (171) Salinipostin H (174) Salinipostin K (177) W2 = 415, 3.22, 8.70 μM, respectively (177) NA graphic file with name d2ra07977a-u145.jpg
Monensin (178) D6 and W2 0.15 to 0.3 nM graphic file with name d2ra07977a-u146.jpg Streptomyces cinnamonensis Marine actinomycetes 147 and 148
Pandaroside E (179) W2 = 0.78.0.05 and 0.038 μM graphic file with name d2ra07977a-u147.jpg Pandaros acanthifolium Sponge 150
Pandaroside G (180) graphic file with name d2ra07977a-u148.jpg
Pandaroside H (181) graphic file with name d2ra07977a-u149.jpg
a

NA: not available.