A list of marine-derived phosphotriesters, polyether, and steroidal glycosides antimalarial drugs showing their IC50 against various strains of Plasmodium sp., chemical structure and biogenic sourcea.
Compound | Antiplasmodial activity (IC50 value) | Structure | Source | Marine class | Ref. |
---|---|---|---|---|---|
Salinipostin A (167) Salinipostin F (172) Salinipostin I (175) | W2 = 50, 266, and 126 nM | Salinospora sp. | Marine actinomycetes | 146 | |
Salinipostin B (168) Salinipostin D (170) Salinipostin G (173) Salinipostin J (176) | W2 = 139, 82, 1.52 μM, respectively (176) NA | ||||
Salinipostin C (169) Salinipostin E (171) Salinipostin H (174) Salinipostin K (177) | W2 = 415, 3.22, 8.70 μM, respectively (177) NA | ||||
Monensin (178) | D6 and W2 0.15 to 0.3 nM | Streptomyces cinnamonensis | Marine actinomycetes | 147 and 148 | |
Pandaroside E (179) | W2 = 0.78.0.05 and 0.038 μM | Pandaros acanthifolium | Sponge | 150 | |
Pandaroside G (180) | |||||
Pandaroside H (181) |
NA: not available.