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The Define-Enrich-Find strategy for early detection of pancreatic cancer. Legend: Screening for sporadic PDAC in the average risk general population is considered unrealistic because of the low incidence. An alternative to screening is a proposed DEF (Define, Enrich, Find) strategy that allows PDAC surveillance in a subset of higher risk asymptomatic patients where it might be most beneficial. New-onset diabetes or pancreatic cysts may be such targeted populations.
