Table 1.

Hereditary Genetic or Cancer Syndroms and PDAC Risk.

Syndrome	Mutation	Lifetime risk %
Peutz-Jeghers syndrome	STK11 (LKB1)	11-32
Hereditary pancreatitis	PRSS1	25-40
FAMMM	P16INK4A/CDKN2A	17
Lynch syndrome (HNPCC)	MLH1, MSH2, MSH6, PMS2, EPCAM	8.6
FAP	APC	1.7
Cystic fibrosis	CFTR	<5
HBOC syndrome	BRCA1, BRCA2/FANCD1, PALB2/FANCN, FANCC, FANCG	Increased
Ataxia telangiectasia	ATM	Increased

FAMMM, Familial atypical multiple mole melanoma syndrome; FAP, familial adenomatous polyposis; FDR, first degree relative; HBOC, hereditary breast and ovarian cancer; HNPCC, hereditary nonpolyposis colorectal cancer; PDAC, pancreatic ductal adenocarcinoma.