Table 1.
Baseline Characteristics
| Characteristics | No Treatment (n = 10) | Atorvastatin (n = 20) | P-Value |
|---|---|---|---|
| Age, y, median (IQR) | 35 (28–37) | 44 (32–52) | 0.16 |
| Male sex, n (%) | 5 (50) | 9 (45) | 0.80 |
| Body mass index, kg/m2 | 28 ± 6 | 28 ± 7 | 0.97 |
| Caucasian, n (%) | 6 (60) | 15 (75) | 0.40 |
| Systolic blood pressure (mm Hg) | 121 ± 10 | 127 ± 17 | 0.40 |
| Diastolic blood pressure (mm Hg) | 75 | 76 ± 12 | 0.87 |
| ACC/AHA ASCVD Risk Score, % | 2.7 ± 3.5 | 3.3 ± 5.4 | 0.77 |
| Psoriasis | |||
| PASI score, median (IQR) | 5.6 (3.2–19) | 4.0 (3.6–6.9) | 0.69 |
| Psoriasis duration, y, median (IQR) | 8 (3–10) | 20 (12–29) | 0.01 |
| Psoriatic arthritis, n (%) | 3 (15) | 4 (40) | 0.13 |
| Biologic therapy, n (%) | 6 (60) | 6 (30) | 0.11 |
| Laboratory studies | |||
| WBC, ×103 cells/mm3, median (IQR) | 7.9 (6.1–9.9) | 6.2 (5.3–7.1) | 0.11 |
| hs-CRP, mg/l, median (IQR) | 2.1 (1.0–4.2) | 1.7 (0.8–2.0) | 0.45 |
| IL-17A, NPX, median (IQR) | 3.5 (1.8–6.1) | 2.4 (1.8–3.6) | 0.43 |
| IL-6, NPX, median (IQR) | 3.8 (3.4–4.6) | 3.3 (3.1–4.2) | 0.20 |
| TNF-α, NPX, median (IQR) | 3.9 (3.7–4.7) | 3.6 (3.3–3.9) | 0.22 |
| Lipids | |||
| Total cholesterol, mg/dl, median (IQR) | 179 (178–186) | 182 (162–216) | 0.79 |
| Triglyercides, mg/dl, median (IQR) | 83 (58–150) | 85 (61–104) | 0.98 |
| LDL-C, mg/dl, median (IQR) | 111 (110–121) | 108 (83–131) | 0.20 |
| HDL-C, mg/dl, median (IQR) | 45 (43–52) | 56 (46–63) | 0.07 |
| meanEC, median (IQR) | 5.9 (2.8–13) | 4.7 (3.2–7.4) | 0.96 |
Abbreviations: ACC/AHA, American College of Cardiology/American Heart Association; ASCVD, atherosclerotic cardiovascular disease; HDL-C, high-density lipoprotein cholesterol; hs-CRP, high-sensitivity CRP; IQR, interquartile range; LDL-C, low-density lipoprotein cholesterol; meanEC, mean expression of proinflammatory vascular endothelial transcript; NPX, normalized eXpression unit; WBC, white blood cell.
Data are presented as mean ± SD or n (%) unless otherwise stated. meanEC indicates mean vascular endothelial transcript inflammation (arbitrary units standardized to the housekeeping gene hARP).