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Biophysical characterization of hybrid vectors at various polymer doses. (A) Sheep red blood cell (RBC) hemolysis. (B) Hybrid membrane shear studies with 5 s sonication. (C) DNA and (D) protein release. *Statistical significance (95% confidence) compared to respective polymers (panel A) or bacterial (panel B) and PBS (panels C and D) controls. Abbreviations: CPLA-26, C26; CPLA-54, C54; PEG-b-CPLA-20, PC20; PEG-b-CPLA-50, PC50.
