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. 2023 Jan 19;12:1048127. doi: 10.3389/fonc.2022.1048127

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Copyright © 2023 Guo, Lu and Xiong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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irAE-related genes were involved in oncogenic and other pathways. (A) The RAF1 and RTK-RAS signaling pathway. Pathway graphs were generated by using the cBioPortal website. (B) The MLXIPL and MYC signaling pathway. (C) GO enrichment of genes regulated by irAE-correlated enhancer ENSR00000326714. (D) GO enrichment of genes regulated by ORR-correlated enhancer ENSR00000164478. (E) KEGG pathway enrichment of genes regulated by ORR-correlated enhancer ENSR00000164478.