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. 2023 Jan 21;15:17588359221146137. doi: 10.1177/17588359221146137

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© The Author(s), 2023

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Absolute (pooled) rates for grade ⩾3 AEs for FTD/TPI + BEV and FTD/TPI monotherapy. (a) FTD/TPI + BEV: Grade ⩾3 neutropenia. (b) FTD/TPI monotherapy: Grade ⩾3 neutropenia. (c) FTD/TPI + BEV: Grade ⩾3 febrile neutropenia. (d) FTD/TPl monotherapy: Grade ⩾3 febrile neutropenia. (e) FTD/TPI + BEV: Grade ⩾3 asthenia/fatigue. (f). FTD/TPI monotherapy: Grade ⩾3 asthenia/fatigue. (g) FTD/TPI + BEV: Grade ⩾3 diarrhea. (h) FTD/TPI monotherapy: Grade ⩾3 diarrhea. (i) FTD/TPI + BEV: Grade ⩾3 nausea. (j) FTD/TPI monotherapy: Grade ⩾3 nausea. (k) FTD/TPI + BEV: Grade ⩾3 vomiting. (l) FTD/TPI monotherapy: Grade ⩾3 vomiting.

AEs, adverse events; CI, confidence interval; FE, fixed effects; FTD/TPI, trifluridine/tipiracil; FTD/TPI + BEV, trifluridine/tipiracil + bevacizumab; RE, random effects.